Cerebrosides and a Monoacylmonogalactosylglycerol from Clinacanthus nutans

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Cerebrosides and a monoacylmonogalactosylglycerol from Clinacanthus nutans.

A mixture of nine cerebrosides and a monoacylmonogalactosylglycerol were separated from the leaves of Clinacanthus nutans. The structures of the cerebrosides were characterized as 1-O-beta-D-glucosides of phytosphingosines, which comprised a common long-chain base, (2S,3S,4R,8Z)-2-amino-8(Z)-octadecene-1,3,4-triol with nine 2-hydroxy fatty acids of varying chain lengths (C(16), C(18), C(20-26))...

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Chemical constituents and bioactivities of Clinacanthus nutans aerial parts.

Four new sulfur-containing compounds, named clinamides A-C (1-3), and 2-cis-entadamide A (4), were isolated together with three known compounds from the bioactive ethanol extract of the aerial parts of Clinacanthus nutans. These secondary metabolites possess sulfur atoms and acrylamide functionalities. The structures of the isolated components were established by interpretation of their spectro...

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Effects of Clinacanthus nutans (Burm.f) Lindau leaf extracts on protection of plasmid DNA from riboflavin photoreaction

Clinacanthus nutans (Burm.f) (CN) Lindau is widely grown in tropical Asia and is an important herbal medicine in China, Malaysia and Thailand. This study inspects the antioxidant activity and protective effects of Clinacanthus nutans extracts on plasmid DNA integrity in E. coli. The antioxidant activities of Clinacanthus nutans are lower compared with green tea. The superoxide dismutase (SOD) a...

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Cytotoxicity evaluation of Clinacanthus nutans through dimethylthiazol diphenyltetrazolium bromide and neutral red uptake assays.

OBJECTIVES The aim of this study was to compare the results of dimethylthiazol diphenyltetrazolium bromide (MTT) and neutral red uptake (NRU) assays of Clinacanthus nutans cytotoxicity. MATERIALS AND METHODS Mouse fibroblast (L929) cells were exposed to 0.01%, 0.1%, 0.25%, and 0.5% (W/V) C. nutans in a 96-cluster-well-culture plate for 24 h. The cell viability after exposure to C. nutans was ...

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Kinetics Extraction Modelling and Antiproliferative Activity of Clinacanthus nutans Water Extract

Clinacanthus nutans is widely grown in tropical Asia and locally known "belalai gajah" or Sabah snake grass. It has been used as a natural product to treat skin rashes, snake bites, lesion caused by herpes, diabetes, fever, and cancer. Therefore, the objectives of this research are to determine the maximum yield and time of exhaustive flavonoids extraction using Peleg's model and to evaluate po...

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 2004

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.52.27